Acteurs : Acteur Jean-Noël FREUND



Dr Jean-Noël FREUND



Equipe de recherche


Equipe A28 – Jean-Noël FREUND •

Axes du CGE

4 : Contrôle de la dissémination tumorale – Plasticité cellulaire, hétérogénéité tumorale et réaction stromale


Equipe A28

Bernard DUCLOS
Isabelle DULUC
Isabelle GROSS
Isabelle HINKEL
Elisabeth MARTIN
Benjamin RENOUF
Thouieba SAANDI



Equipe A28

2007 – ACM-07 (porteur : Eric SOLARY)
Anomalies de l’activation des caspases dans la leucémie myélo-monocytaire chronique et les syndromes myélodysplasiques et rôle de Cdx2 dans leur transformation blastique

2007 – RIO2007 (porteur : Marie-Christine RIO)
Early determination of aggressiveness of primary tumors

2006 – CDX2 (porteur : Jean-Noël FREUND)
The homeobox gene CDX2: a new therapeutic target against dissemination of colorectal cancer cells

2005 – CDX2 (porteur : Jean-Noël FREUND)
Reversible alteration of the expression of the homeotic tumour suppressor CDX2 during tumour cell invasion in colorectal cancers

2004 – RIO2004 (porteur : Marie-Christine RIO)
Nature and function of the molecular actors involved in local tumor invasion

Projets hors INCa

Equipe A28

2007 – AICR – #08-0199
2007 – ARC – #4872






Pons L, Battaglia-Hsu SF, Orozco-Barrios CE, Ortiou S, Chery C, Alberto JM, Arango-Rodriguez ML, Dumas D, Martinez-Fong D, Freund JN, Gueant JL. Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin. PLoS One. 2009 Jul 22;4(7):e6325.


Modica S, Morgano A, Salvatore L, Petruzzelli M, Vanier MT, Valanzano R, Esposito DL, Palasciano G, Duluc I, Freund JN, Mariani-Costantini R, Moschetta A. Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2. Gut. 2009 Sep;58(9):1250-9. Epub 2009 Feb 15.




Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I. Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3. Epub 2008 Jun 25.


Hajj Hussein IA, Tohme R, Barada K, Mostafa MH, Freund JN, Jurjus RA, Karam W, Jurjus A. Inflammatory bowel disease in rats: bacterial and chemical interaction. World J Gastroenterol. 2008 Jul 7;14(25):4028-39.


Barros R, Pereira B, Duluc I, Azevedo M, Mendes N, Camilo V, Jacobs RJ, Paulo P, Santos-Silva F, van Seuningen I, van den Brink GR, David L, Freund JN, Almeida R. Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines. J Pathol. 2008 Aug;215(4):411-20.


Bonhomme C, Calon A, Martin E, Robine S, Neuville A, Kedinger M, Domon-Dell C, Duluc I, Freund JN. Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene. 2008 Jul 24;27(32):4497-502. Epub 2008 Mar 31.


Lu X, Freund JN, Muller M, Ravey J, Nicolas JP, Gueant JL, Namour F. Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. Biochimie. 2008 May;90(5):697-704. Epub 2007 Dec 23.


Choquet P, Calon A, Breton E, Beck F, Domon-Dell C, Freund JN, Constantinesco A. Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice. C R Biol. 2007 Nov;330(11):821-7. Epub 2007 Sep 7.


Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, Kedinger M, Domon-Dell C, Freund JN. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene. 2008 Jan 3;27(1):107-15. Epub 2007 Jun 25.


Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN. Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut. 2007 Dec;56(12):1688-95. Epub 2007 Jun 26.


Jonckheere N, Vincent A, Perrais M, Ducourouble MP, Male AK, Aubert JP, Pigny P, Carraway KL, Freund JN, Renes IB, Van Seuningen I. The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells. J Biol Chem. 2007 Aug 3;282(31):22638-50. Epub 2007 Jun 6.


Coste I, Freund JN, Spaderna S, Brabletz T, Renno T. Precancerous lesions upon sporadic activation of beta-catenin in mice. Gastroenterology. 2007 Apr;132(4):1299-308. Epub 2007 Jan 21.


Buchet-Poyau K, Courchet J, Le Hir H, Seraphin B, Scoazec JY, Duret L, Domon-Dell C, Freund JN, Billaud M. Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies. Nucleic Acids Res. 2007;35(4):1289-300. Epub 2007 Jan 31.


Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I. The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. Am J Pathol. 2007 Feb;170(2):733-44.


Calon A, Gross I, Davidson I, Kedinger M, Duluc I, Domon-Dell C, Freund JN. Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Res. 2007;35(1):175-85. Epub 2006 Dec 7.


Subtil C, Guerin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN. Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Lett. 2007 Mar 18;247(2):197-203. Epub 2006 May 30.


Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P, Pitari GM, Schulz S, Waldman SA. Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology. 2006 Apr;130(4):1191-206.


Kim HS, Lee JS, Freund JN, Min KW, Lee JS, Kim W, Juhng SW, Park CS. CDX-2 homeobox gene expression in human gastric carcinoma and precursor lesions. J Gastroenterol Hepatol. 2006 Feb;21(2):438-42.


Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN. Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene. 2005 Dec 1;24(54):7955-63.


Turck N, Gross I, Gendry P, Stutzmann J, Freund JN, Kedinger M, Simon-Assmann P, Launay JF. Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Exp Cell Res. 2005 Feb 15;303(2):494-503. Epub 2004 Nov 18.


Brabletz T, Spaderna S, Kolb J, Hlubek F, Faller G, Bruns CJ, Jung A, Nentwich J, Duluc I, Domon-Dell C, Kirchner T, Freund JN. Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res. 2004 Oct 1;64(19):6973-7.


Blache P, van de Wetering M, Duluc I, Domon C, Berta P, Freund JN, Clevers H, Jay P. SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes. J Cell Biol. 2004 Jul 5;166(1):37-47.


Wang L, Klopot A, Freund JN, Dowling LN, Krasinski SD, Fleet JC. Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha. Am J Physiol Gastrointest Liver Physiol. 2004 Nov;287(5):G943-53. Epub


Kim SP, Park JW, Lee SH, Lim JH, Jang BC, Lee SH, Jang IH, Freund JN, Suh SI, Mun KC, Song DK, Ha EM, Lee WJ, Kwon TK. Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer. Biochem Biophys Res Commun. 2004 Feb 27;315(1):93-9.


Tohyama O, Imura A, Iwano A, Freund JN, Henrissat B, Fujimori T, Nabeshima Y. Klotho is a novel beta-glucuronidase capable of hydrolyzing steroid beta-glucuronides. J Biol Chem. 2004 Mar 12;279(11):9777-84. Epub 2003 Dec 29.


Kim S, Domon-Dell C, Kang J, Chung DH, Freund JN, Evers BM. Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop. J Biol Chem. 2004 Feb 6;279(6):4285-91. Epub 2003 Nov 17.


Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN. Cdx1 homeobox gene during human colon cancer progression. Oncogene. 2003 Sep 11;22(39):7913-21.