Acteurs : Acteur Isabelle GROSS

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Nom
Dr Isabelle GROSS
Coordonnées
Affiliation(s)
Equipe de recherche
Equipe A28 – Jean-Noël FREUND •
Axes du CGE
4 : Contrôle de la dissémination tumorale – Plasticité cellulaire, hétérogénéité tumorale et réaction stromale
Collègues
Equipe A28

  • Lylia DERBAL
  • Claire DOMON-DELL
  • Bernard DUCLOS
  • Isabelle DULUC
  • Jean-Noël FREUND
  • Isabelle HINKEL
  • Elisabeth MARTIN
  • Nadine PLATET
  • Benjamin RENOUF
  • Thouieba SAANDI
  • Marie VANIER
Projets
Equipe A28

2007 – ACM-07 (porteur : Eric SOLARY)
Anomalies de l’activation des caspases dans la leucémie myélo-monocytaire chronique et les syndromes myélodysplasiques et rôle de Cdx2 dans leur transformation blastique
2007 – RIO2007 (porteur : Marie-Christine RIO)
Early determination of aggressiveness of primary tumors
2006 – CDX2 (porteur : Jean-Noël FREUND)
The homeobox gene CDX2: a new therapeutic target against dissemination of colorectal cancer cells
2005 – CDX2 (porteur : Jean-Noël FREUND)
Reversible alteration of the expression of the homeotic tumour suppressor CDX2 during tumour cell invasion in colorectal cancers
2004 – RIO2004 (porteur : Marie-Christine RIO)
Nature and function of the molecular actors involved in local tumor invasion
Projets hors INCa
Equipe A28

  • 2007 – AICR – #08-0199
  • 2007 – ARC – #4872
Publications


Meng X, Leyva ML, Jenny M, Gross I, Benosman S, Fricker B, Harlepp S, Hebraud P, Boos A, Wlosik P, Bischoff P, Sirlin C, Pfeffer M, Loeffler JP, Gaiddon C. A ruthenium-containing organometallic compound reduces tumor growth through induction of the endoplasmic reticulum stress gene CHOP. Cancer Res. 2009 Jul 1;69(13):5458-66. Epub 2009 Jun 23.

Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I. Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3. Epub 2008 Jun 25.

Benosman S, Gross I, Clarke N, Jochemsen AG, Okamoto K, Loeffler JP, Gaiddon C. Multiple neurotoxic stresses converge on MDMX proteolysis to cause neuronal apoptosis. Cell Death Differ. 2007 Dec;14(12):2047-57. Epub 2007 Sep 7.

Gross I, Armant O, Benosman S, de Aguilar JL, Freund JN, Kedinger M, Licht JD, Gaiddon C, Loeffler JP. Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death Differ. 2007 Oct;14(10):1802-12. Epub 2007 Jun 29.

Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, Kedinger M, Domon-Dell C, Freund JN. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene. 2008 Jan 3;27(1):107-15. Epub 2007 Jun 25.

Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN. Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut. 2007 Dec;56(12):1688-95. Epub 2007 Jun 26.

Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I. The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. Am J Pathol. 2007 Feb;170(2):733-44.

Calon A, Gross I, Davidson I, Kedinger M, Duluc I, Domon-Dell C, Freund JN. Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Nucleic Acids Res. 2007;35(1):175-85. Epub 2006 Dec 7.

Turck N, Lefebvre O, Gross I, Gendry P, Kedinger M, Simon-Assmann P, Launay JF. Effect of laminin-1 on intestinal cell differentiation involves inhibition of nuclear nucleolin. J Cell Physiol. 2006 Feb;206(2):545-55.

Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN. Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene. 2005 Dec 1;24(54):7955-63.

Turck N, Gross I, Gendry P, Stutzmann J, Freund JN, Kedinger M, Simon-Assmann P, Launay JF. Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells. Exp Cell Res. 2005 Feb 15;303(2):494-503. Epub 2004 Nov 18.
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