Acteurs : Acteur Elisabeth MARTIN

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Nom
Mme Elisabeth MARTIN
Coordonnées
Affiliation(s)
Equipe de recherche
Equipe A28 – Jean-Noël FREUND •
Aires d’expertise
Cancer:ColorectalRecherche:Biologie CellulaireRecherche:Biologie Moléculaire
Axes du CGE
4 : Contrôle de la dissémination tumorale – Plasticité cellulaire, hétérogénéité tumorale et réaction stromale
Collègues
Equipe A28

  • Lylia DERBAL
  • Claire DOMON-DELL
  • Bernard DUCLOS
  • Isabelle DULUC
  • Jean-Noël FREUND
  • Isabelle GROSS
  • Isabelle HINKEL
  • Nadine PLATET
  • Benjamin RENOUF
  • Thouieba SAANDI
  • Marie VANIER
Projets
Equipe A28

2007 – ACM-07 (porteur : Eric SOLARY)
Anomalies de l’activation des caspases dans la leucémie myélo-monocytaire chronique et les syndromes myélodysplasiques et rôle de Cdx2 dans leur transformation blastique
2007 – RIO2007 (porteur : Marie-Christine RIO)
Early determination of aggressiveness of primary tumors
2006 – CDX2 (porteur : Jean-Noël FREUND)
The homeobox gene CDX2: a new therapeutic target against dissemination of colorectal cancer cells
2005 – CDX2 (porteur : Jean-Noël FREUND)
Reversible alteration of the expression of the homeotic tumour suppressor CDX2 during tumour cell invasion in colorectal cancers
2004 – RIO2004 (porteur : Marie-Christine RIO)
Nature and function of the molecular actors involved in local tumor invasion
Projets hors INCa
Equipe A28

  • 2007 – AICR – #08-0199
  • 2007 – ARC – #4872
Publications


Benahmed F, Gross I, Gaunt SJ, Beck F, Jehan F, Domon-Dell C, Martin E, Kedinger M, Freund JN, Duluc I. Multiple regulatory regions control the complex expression pattern of the mouse Cdx2 homeobox gene. Gastroenterology. 2008 Oct;135(4):1238-1247, 1247.e1-3. Epub 2008 Jun 25.

Bonhomme C, Calon A, Martin E, Robine S, Neuville A, Kedinger M, Domon-Dell C, Duluc I, Freund JN. Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer. Oncogene. 2008 Jul 24;27(32):4497-502. Epub 2008 Mar 31.

Gross I, Duluc I, Benameur T, Calon A, Martin E, Brabletz T, Kedinger M, Domon-Dell C, Freund JN. The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene. 2008 Jan 3;27(1):107-15. Epub 2007 Jun 25.

Calon A, Gross I, Lhermitte B, Martin E, Beck F, Duclos B, Kedinger M, Duluc I, Domon-Dell C, Freund JN. Different effects of the Cdx1 and Cdx2 homeobox genes in a murine model of intestinal inflammation. Gut. 2007 Dec;56(12):1688-95. Epub 2007 Jun 26.

Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I. The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. Am J Pathol. 2007 Feb;170(2):733-44.

Subtil C, Guerin E, Schneider A, Chenard MP, Martin E, Domon-Dell C, Duluc I, Brabletz T, Kedinger M, Duclos B, Gaub MP, Freund JN. Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability. Cancer Lett. 2007 Mar 18;247(2):197-203. Epub 2006 May 30.

Gross I, Lhermitte B, Domon-Dell C, Duluc I, Martin E, Gaiddon C, Kedinger M, Freund JN. Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation. Oncogene. 2005 Dec 1;24(54):7955-63.

Domon-Dell C, Schneider A, Moucadel V, Guerin E, Guenot D, Aguillon S, Duluc I, Martin E, Iovanna J, Launay JF, Duclos B, Chenard MP, Meyer C, Oudet P, Kedinger M, Gaub MP, Freund JN. Cdx1 homeobox gene during human colon cancer progression. Oncogene. 2003 Sep 11;22(39):7913-21.
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